A Multi-Centers Comparative Study of Extensive and Deep Degree Burns of Children
Journal of US-China Medical Science
Objective: To summarize and assess the therapeutic effects of Burns Regenerative Medicine and Therapy (BRT) and Eschar Excision and Skin Grafting Techniques (SGT) on extensive and deep degree pediatric burns treatment. Methods: A multi-center controllable randomization comparative method was used in this study. The 69 pediatric in-patients with extensive and deep degree burns that from 7 centers in 3 countries were separate randomization into test group (37 cases were treated with BRT) and
... with BRT) and control group (32 cases were treated with SGT). The main outcome measures included average usage rates of analgesic in treatment, wound infection rates, skin grafting rates, average wound healing time, scar hyperplasia rates after treatment, dysfunction rates and mortality. Statistical analysis was applied to the data of both groups. Results: No significant difference was found in mortality between test group (2.70%) and control group (3.13%); The results of t-test or x 2 -test of other main outcome measures showed significant difference (P < 0.01) between the two groups. Conclusion: Burns regenerative medicine and therapy provides a more satisfactory treatment for extensive and deep degree pediatric burns. Key words: Pediatric burns, extensive and deep degree burns, burns regenerative medicine and therapy, moist exposed burns ointment (MEBO), eschar excision, skin grafting technique.