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T-helper-cell cytokines in the early evolution of murine Lyme arthritis
Infection and Immunity
Genetic susceptibility to murine Lyme arthritis has been correlated with the dominance of T-helper (Th1)or Th2-cell-associated cytokines. To determine when commitment of the Th cell phenotype occurs, we examined the kinetics of gamma interferon (IFN-␥) and interleukin-4 (IL-4) production by lymph node T cells of disease-susceptible C3H/HeN and disease-resistant BALB/c mice from days 2 through 30 of infection, a period encompassing the evolution of disease and early regression. BALB/c micedoi:10.1128/iai.65.8.3107-3111.1997 fatcat:m6uuku7bdnbxziraxhkgfntxvy