Seroprevalence Of Hepatitis B Surface Antigen Among Prospective Blood Donors In An Urban Area Of Benue State

2009 The Internet Journal of Hematology  
Rheumatoid Arthritis (RA) is a chronic inflammatory disorder which can cause oxidative stress [1] . The main characteristic of the disease is inflammation of synovial membrane with swelling and pain that ultimately leads to the destruction of cartilage and bone [2] .Routine clinical practices in management of rheumatoid arthritis aim at reducing the patients' pain and joint inflammation, minimizing loss of function and decrease the progression of joint damage.Methods: In this double
more » ... zed clinical trial, 90 patients were included who were divided into three groups based on received drugs (group EO: one omega-3 capsule (1g/d of fish oil,) plus one vitamin E capsule (400 IU/d); group O: one omega-3 capsule plus placebo of vitamin E; group P: placebo of omega-3 and vitamin E). At the beginning and end of the study, all patients were examined, 72-h recall was completed and 10 ml of fasting blood sample was obtained to assess the serum levels of malondialdehyde (MDA), plasma antioxidant capacity (TAC) and C-reactive protein (CRP) as well as the activity of superoxide dismutase (SOD) and Glutathione peroxides (GPX).Results: In group (EO), there was a significant decrease in lipid peroxidation (MDA concentration) compared with the other groups (P= 0.032). None of the interventions could affect the activity of antioxidant enzymes, SOD and GPX, or total antioxidant capacity of serum. Also there was no significant improvement in the clinical outcomes of different groups. Conclusion: Omega-3 and vitamin E supplements in the prescribed doses did not show any beneficial effect on clinical outcomes of the patients or activity of antioxidant enzymes, however adding vitamin E supplements to omega 3 fatty acid supplements could reduced MDA levels comparing to omega 3 fatty acids alone or placebo.
doi:10.5580/1c fatcat:hs7xleittbg67ggftlp6llpve4