The Inclusion Complex Formation of Epigallocatechin Gallate in γ-Cyclodextrin and Its Effect on the Antioxidant Activity
Transactions of the Materials Research Society of Japan
The inclusion complex formation of epigallocatechin gallate (EGCg) in γcyclodextrin (γCD) was investigated. There are already several reports about the complex formation of several kinds of catechin in β or γCD, but no report about EGCg in γCD. 1 HNMR spectra and UV absorption spectra gave the proof of the inclusion complex formation of EGCg in γCD and the binding constant EGCg in γCD was similar to that of gallocatechin gallate (GCg) in γCD, which was previously reported. The effect
... the complex formation on the antioxidant activity of EGCg was also investigated. The antioxidant activity of EGCg against DPPH radical was not inhibited but slightly enhanced by the complex formation in γCD. These data gave the proof of the inclusion complex formation of EGCg in γCD for the first time. As EGCg shows the strongest antioxidant activity among the series of catechins and γCD adapts highly to the food safety regulation compared with other CDs, the inclusion complex formation of EGCg in γCD is valuable in the field of pharmaceutics, cosmetics and food industries.