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Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents
Science Translational Medicine
Nerve agents are a class of organophosphorus compounds (OPs) that blocks communication between nerves and organs. Because of their acute neurotoxicity, it is extremely difficult to rescue the victims after exposure. Numerous efforts have been devoted to search for an effective prophylactic nerve agent bioscavenger to prevent the deleterious effects of these compounds. However, low scavenging efficiency, unfavorable pharmacokinetics, and immunological problems have hampered the development ofdoi:10.1126/scitranslmed.aau7091 pmid:30602537 fatcat:ievljc63snd4zbwxnuxxbmzoka