Studies on the Antimicrobial Resistance Pattern of Bacterial Pathogens isolated from Cancer Patients

Moneeza Abbas, Jamal Kausar, Cheema, Mariam Faiz
BIOLOGIA (PAKISTAN)   unpublished
The present study deals with the antimicrobial resistance pattern of different antimicrobials being used to treat infections in cancer patients. The isolated strains were tested against antibiotics belonging to cephalosporin and aminoglycoside groups. The activity of these drugs was evaluated against 50 bacterial strains isolated from cancer patients undergoing anticancer therapy. The susceptibility was determined by broth dilution method according to British Standard Antimicrobial Chemother
more » ... robial Chemother (BSAC, 2003) USA guidelines. The overall Minimum Inhibitory Concentration (MIC) was determined at which 50 and 90 percent of bacterial isolates were inhibited. The resistance of Gram positive isolates against Cefoperazone, Ceftrixone and Ampicillin was 0%, 30% and 68% respectively. Whereas Pseudomonas aeruginosa among Gram negative bacteria showed resistance against Cefoperazone, Ceftriaxone and Ampicillin which was 0%, 27% and 64% respectively. For Enterobactericeae, it was recorded as 0%, 10% and 91% respectively. The order of activity against Gram-negative and Gram positive strains was Cefoperazone> Ceftriaxone >Ampicillin. Overall frequency of isolation of Gram positive bacteria and Gram-negative bacteria was 56% and 44% respectively. The results are useful with reference to the current resistance and susceptibility pattern among isolates against cephalosporin and aminoglycosides.