1.1. Aims: Thymidine Kinase 1(TK1) is a precision protein molecular target for assessment of tumor proliferating rate. This investigation of 3 cases is whether the elevated STK1p after the 2-cycle -chemotherapy is associated with failure poor survival of clinical stage I-II in Non-Small-Cell Lung Carcinomas (NSCLCs). Main Methods: The 3 post-operative NSCLCs with clinical stage I-II were confirmed by pathology and followed by individual chemotherapy. The Serum Thymidine Kinase 1 protein (STK1p)

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... was measured using the ECL dot blot assay. Results: Although the 3 cases are of early clinical stage I-II, an increasing STK1p following by the second cycle of chemotherapy was observed. The elevated STK1p appeared 3-17 months early as compared the tumor metastasis by CT, and the Response Evaluation Criteria in Solid Tumors was evaluated as stable disease. The 3 patients died due to the failure poor survival. Significance: The post-radical resection following by 2 cycle-chemotherapy is important critical-point time to measure STK1p if the value is increasing or decline. The elevated STK1p values can predict an earlier risk of tumor metastasis process than imaging. It can supply a strong advance advice to adapt a new individual treatment for a better prognosis in the NSCLCs in routing clinical setting.