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The authors propose a paradigm shift in the investigation of the self. Synthesizing neuroimaging results from studies investigating the self, the authors first demonstrate that self-relatedness evaluation involves a wide cerebral network, labeled E-network, comprising the medial prefrontal cortex, precuneus, temporoparietal junction, and temporal poles. They further show that this E-network is also recruited during resting state, others' mind reading, memory recall, and reasoning. According todoi:10.1037/a0014172 pmid:19159156 fatcat:aftuw5nuujh6nnfh3roaq5p3ma