The rising frequency of drugs which having poor solubility, manufacturability and stability in development offers notable risk of new drug products which having low and variable bioavailability particularly for those drugs administrated by the oral route, with consequences for safety and efficacy. Although, number of strategies exists for enhancing the bioavailability of those drugs, these strategies are greatly dependent on the physical and chemical nature of the molecules being developed.

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... tal engineering approach presents a number of routes such as co-crystallization, polymorphism and salt formation to improve physico-chemical properties of drugs, which can be implemented through an in detail knowledge of crystallization processes and the molecular properties of drugs. Various polymorphs usually have different physico-chemical, mechanical and thermal properties that can extremely affect the bioavailability, stability and other characteristics of the active pharmaceutical ingredients. This article covers the concept of crystal engineering approach and discusses the potential advantages, disadvantages a n d m e t h o d s o f p r e p a r a t i o n o f c o-c r y s t a l s , r e c e n t a d v a n c e s i n t h e i n v e n t i o n a n d c o n t r o l o f t h e polymorphs of drug molecules, in terms of the development of the selective nucleation of a particular polymorph.