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The signalling factor PI3K is a specific regulator of the clathrin-independent dynamin-dependent endocytosis of IL-2 receptors
2013
Journal of Cell Science
Receptor-mediated endocytosis is an essential process used by eukaryotic cells to internalise many molecules. Several clathrinindependent endocytic routes exist, but the molecular mechanism of each pathway remains to be uncovered. The present study focuses on a clathrin-independent dynamin-dependent pathway used by interleukin 2 receptors (IL-2R), essential players of the immune response. Ras-related C3 botulinum toxin substrate (Rac1) and its targets, the p21-activated kinases (Pak), are
doi:10.1242/jcs.110932
pmid:23345407
fatcat:gvahn4iobjbinhrd2t3kvivdnu