Automated classification of Schistosoma mansoni granulomatous microscopic images of mice liver using Artificial Intelligence (AI) technologies is a key issue for accurate diagnosis and treatment. In this paper, three grey difference statistics-based features, namely three Gray-Level Co-occurrence Matrix (GLCM) based features and fifteen Gray Gradient Co-occurrence Matrix (GGCM) features were calculated by correlative analysis. Ten features were selected for three-level cellular granuloma

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... ication using a Scaled Conjugate Gradient Back-Propagation Neural Network (SCG-BPNN) in the same performance. A cross-entropy is then calculated to evaluate the proposed Sigmoid input and the ten-hidden layer network. The results depicted that SCG-BPNN with texture features performs high recognition rate compared to using morphological features, such as shape, size, contour, thickness and other geometry-based features for the classification. The proposed method also has a high accuracy rate of 87.2% compared to the Back-Propagation Neural Network (BPNN), Back-Propagation Hopfield Neural Network (BPHNN) and Convolutional Neural Network (CNN).