A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia
2015
Cancer Genetics
Preserved Fulltext
Acquired aplastic anemia (aAA) is a non-malignant disease caused by autoimmune destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20-25% of older patients. We hypothesized that clonal hematopoiesis in aAA is a more general phenomenon, which can arise early in disease even in younger patients. To evaluate clonal hematopoiesis in aAA, we used comparative whole exome sequencing of paired bone marrow and skin in 22 patients. We found somatic mutations in
doi:10.1016/j.cancergen.2015.01.007
pmid:25800665
pmcid:PMC4433860
fatcat:xueobkgfgjeyhc46hscozxucc4