Ni(0)-Catalyzed α-Allylic Alkylation of Regular Ketones with 1,3-Dienes under pH and Redox-neutral Conditions [post]

Tiantian Chen, Yang Yang, Liyu Xie, Haijian Yang, Guangbin Dong, Dong Xing
2018 unpublished
<p>We report a Ni(0)-catalyzed cross coupling reaction between simple ketones and 1,3-dienes. A variety of a-allylic alkylation products were formed in an 1,2-addition manner with excellent regioselectivity. Water was found to significantly accelerate this transformation. A HO-Ni-H species generated from oxidative addition of Ni(0) to H<sub>2</sub>O is proposed to play a "dual role" in activating both the ketone and the diene substrate.</p>
doi:10.26434/chemrxiv.7072646 fatcat:x4eoq73tdjf4fcpeed36hiqhze