Study on the relationship of depression, anxiety, lifestyle and eating habits to the severity of reflux esophagitis
Background: The etiology of reflux esophagitis (RE) is multi-factorial. This study aims to analyze the risk factors of the RE, its severity and further explore the impact of anxiety and depression on the patients' symptoms and quality of life. Methods: From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in the survey. They were divided into RE group (patients diagnosed as RE on gastroscopy, n = 361) and control group (healthy
... rol group (healthy individuals without heartburn, regurgitation and other typical symptoms, n = 328). The survey included general demographic data, lifestyle habits, eating habits, GERD questionnaire (GerdQ), PHQ-9 depression scale and GAD-7 anxiety scale. Results: The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis showed that low education level, drinking strong tea, preference for sweets and acidic foods, overeating, short interval between dinner and sleep, anxiety, depression, sleeping on low pillow and constipation were independent risk factors for RE (p< 0.05). Ordinal logistic regression analysis showed positive correlation between sleeping on low pillow and the severity of RE (p=0.024). Depression had positive correlation with the severity of symptoms (rs=0.375,P<0.001) and the quality of life (rs=0.306,P<0.001), whereas anxiety had no such association. Conclusions: Many lifestyle and eating habits are independent risk factors for the development of RE. Sleeping on low pillow was positively correlated with the severity of RE. Depression was positively related to the severity of symptoms and the quality of life.