Hui Liu,1,* Bailong Liu,1,* Yunfei Ma,1 Liang Guo,2 Di Wu,3 Aiping Shi,3 Min Liu1 1Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China; 2Department of Pathology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China; 3Department of Breast Surgery, The First Hospital of Jilin University, Changchun 130021, People's Republic of China*These authors contributed equally to this workCorrespondence: Aiping

more »

... ShiDepartment of Breast Surgery, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, People's Republic of ChinaTel + 86 133-6430-8696Email sap@jlu.edu.cnMin LiuDepartment of Radiation Oncology, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, People's Republic of ChinaTel + 86 158-0430-2751Email lmin99@jlu.edu.cnAbstract: Locally advanced breast cancer (LABC) is frequently encountered in clinical practice. Primary systemic therapy is regarded as the cornerstone of LABC management to downstage the disease and enable surgery. However, multiple lines of systemic agents may fail to control tumor growth in a considerable number of patients, and few options remain available for such patients. Here, we present a case of triple-negative, right breast cancer that progressed aggressively despite 3 lines of standard chemotherapy. The patient suffered from severe skin ulceration, bleeding, pain, infection, and fungation. The small-molecular tyrosine kinase inhibitor (TKI) apatinib was initiated, which targets vascular endothelial growth factor receptor 2 (VEGFR2). The patient then underwent hypofractionated irradiation applied to the whole right breast at 40 Gy/8 f. The tumor responded dramatically to this combination, and a near-complete remission (CR) response was achieved 2 months after irradiation. Our case is novel and instructional and demonstrated the efficacy and safety of hypofractionated irradiation combined with antiangiogenesis for the treatment of intractable LABC, shedding [...]