Genomic insights into the host specific adaptation of the Pneumocystis genus and emergence of the human pathogen Pneumocystis jirovecii [article]

Ousmane H Cisse, Liang Ma, John P Dekker, Pavel P Khil, Jung-Ho Youn, Jason M Brenchley, Robert V Blair, Bapi Pahar, Magali Chabe, Koen K.A Van Rompay, Rebekah Keesler, Antti Sukura (+13 others)
2020 bioRxiv   pre-print
Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of
more » ... es infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals novel insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.
doi:10.1101/2020.07.29.227421 fatcat:jzqxjtqgindmtakhtwost6ql5m