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Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences
2005
Cardiovascular Research
Increased production of reactive oxygen species (ROS) has been implicated in the pathogenesis of cardiovascular diseases. Enzymatic systems such as the mitochondrial respiratory chain, vascular NAD(P)H oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase (eNOS) produce superoxide anion (O 2 &À ) in vascular cells. While some O 2 &À rapidly degrades by reacting with nitric oxide (NO & ), the O 2 &À signal preserved by dismutation into hydrogen peroxide (H 2 O 2 ) exerts
doi:10.1016/j.cardiores.2005.06.021
pmid:16009356
fatcat:qe4xcfetsbdclorafu2totcvue