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The 1,25(OH)2D3-Regulated Transcription Factor MN1 Stimulates Vitamin D Receptor-Mediated Transcription and Inhibits Osteoblastic Cell Proliferation
The vitamin D endocrine system is essential for maintaining mineral ion homeostasis and preserving bone density. The most bioactive form of vitamin D, 1,25-dihydroxyvitamin D 3 [1,25-(OH) 2 D 3 ] elicits its effects by binding to the vitamin D receptor (VDR) and regulating the transcription of target genes. In osteoblasts, the bone-forming cells of the skeleton, 1,25-(OH) 2 D 3 regulates cell proliferation, differentiation, and mineralization of the extracellular matrix. Despite thesedoi:10.1210/me.2005-0081 pmid:15890672 fatcat:23poj4i35rfatgsjtebxiqyjq4