Antisense thymidylate synthase electrogene transfer to increase uptake of radiolabeled iododeoxyuridine in a murine model

Kwan-Hwa Chi, Hsin-Ell Wang, Yu-Shan Wang, Shun-Lan Chou, Hung-Man Yu, Yu-Hua Tseng, Ing-Ming Hwang, Wing-Yiu Lui
2004 Journal of Nuclear Medicine  
In vitro and in vivo experiments from our laboratory and others have suggested that the combination of thymidylate synthase (TS) inhibitor and radiolabeled iododeoxyuridine (IdUrd) is synergistic. Efficacy is limited by drug resistance, which is often mediated by TS overexpression. We designed an in vivo electrogene transfer (EGT) model for delivering antisense TS plasmid (ATS) into tumor to increase the subsequent efficacy of (131)I-IdUrd therapy.
pmid:15001691 fatcat:xtln7zcptngwlit2npf73d5mdq