Plasma Growth Hormone and Plasma 11-OHCS in Corticosteroid Treated Patients

Reiko Demura, Hiroshi Demura, Masanori Iino, Takashi Nunokawa, Kiyoshi Miura
1970 Tohoku journal of experimental medicine  
Plasma growth hormone and 11-OHCS in response to insulin hypoglycemia were determined simultaneously in corticosteroid treated patients. Long-term daily administration of corticosteroids, more than 800 tablets and longer than 6 months, had a marked inhibitory effect on GH secretion. Lower doses or shorter term administration on daily basis resulted in less suppression. Intermittent administration with various schedules usually had a less inhibitory effect than daily administration. In
more » ... ntly administered patients, better responses were observed in a group tested on off-day than in a group tested on on-day of corticosteroids. A single administration of 1-8 mg of dexamethasone to normal subjects at a midnight before a test had a variable effect on GH secretion. Plasma GH responses to arginine infusion were also suppressed by long-term and high dose administration of corticosteroids. The suppression of GH seemed to go
doi:10.1620/tjem.100.85 fatcat:wkuvgpw3affwzgbqojaccpiase