Oral squamous cell carcinomas developing from oral lichen planus: Do they differ in recurrence and metastatic potential?
Background: Due to the low proportion of squamous cell carcinomas of the oral cavity (OSCC) developing from oral lichen planus (OLP-OSCC) there is only little data regarding the frequency of lymph node metastasis and clinical characteristics such as relapse and outcome in this sub-entity. Therefore, a retrospective analysis of OLP- OSCC was performed. Methods: In a retrospective monocenter analysis, all consecutive patients with an OSCC treated in the time period 2000 to 2016 were composed. All
... were composed. All patients with an OSCC developing from OLP/ OLLs were identified and analyzed for epidemiological data, risk profile, location of primary tumor, pTNM classification, lymph node metastasis, primary therapy, recurrence, and outcome. Results: A total of 103 patients (45%♂/ 55%♀) with an average age of 62 ± 14y were included in this study. At the time of initial diagnosis, 17% (n = 18) of patients had cervical metastases (CM) whereas only 11% (11 patients) displayed advanced tumor sizes (T > 2). T-status (p = 0.003) and histopathological grading (p = 0.001) had an impact on the incidence of CM. 39.6% of the patients developed a relapse after an average of 24 months with a mean of two recurrences per patient. Advanced tumor size had a significant impact on the 5-year overall survival and was associated with disease free survival of the patients (p < 0.001, respectively p = 0.004). Conclusion: Even if initial lymph node metastases were not found more frequent, more aggressive recurrence patterns compared to OSCC could be demonstrated for OLP-OSCC. Therefore, a modified recall for these patients might be necessary.