Gallic Acid Attenuates Dimethylnitrosamine-induced Acute Liver Injury in Mice through Nrf2-mediated Induction of Heme Oxygenase-1 and Glutathione-s-transferase Alpha 3

Shaohua Ma
2014 Medicinal Chemistry  
Dimethylnitrosamine (DMN), a N-nitroso compound commonly occurring in cured food, tobacco products, alcoholic beverages as well as in industrial sewage, has potent hepatotoxicity in mammals. After oxidization catalyzed by CYP450 2E1, DMN is transformed into reactive oxygen intermediates, formaldehyde and methylating species
doi:10.4172/2161-0444.1000208 fatcat:er73mwqdbrc6pl5dnxnom7jnfq