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Altered expression of mitochondrial antioxidants in oral squamous cell carcinoma
Journal of Oral Science
Reactive oxygen species, if produced in excess by oxidative phosphorylation, contributes to mitochondrial DNA damage and progressive respiratory chain dysfunction, leading to various diseases including carcinogenesis. Mitochondria are susceptible to oxidative stress (OS) owing to lack of introns, protective histones, and DNA repair enzymes. However, mitochondria are protected from OS by numerous antioxidants such as superoxide dismutase 2 (SOD2), catalase, glutaredoxin 2 (GLRX2), reduceddoi:10.2334/josnusd.16-0655 pmid:28904321 fatcat:ei5bmuro7bhuhehyc2vs57etfe