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Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2
2015
International Journal of Molecular Sciences
Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, these activation steps bring some dynamic changes on the 3D-structure of the kinase, especially the activation segment. Until now, in the monomeric CDK2 structure, three binding sites have been
doi:10.3390/ijms16059314
pmid:25918937
pmcid:PMC4463590
fatcat:v7uijrrqenc5pnr4nsiwl4flra