Bacngraund/Aim. Regardless of embryos quality, an appropriate endometrial thickness and a successful embryo transfer (ET), implantation remains a difficulty for a favorable outcome of an in vitro fertilization (IVF). Numerous studies with the aim of increasing implantation rate and pregnancy rate suggest local endometrial injury (LEI) prior to the IVF procedure. Hysteroscopy is a method becoming more widely used both with patients after a failed IVF cycle and with patients before the first IVF,

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... considering the large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. However, there is still no consensus reached over LEI, the way and time of its performing or its impact. The aim of this research was to determine the effect of hysteroscopically made local endometrial lesion on the IVF procedure outcome, both in the first and in the next IVF cycle and also to examine if the new method of LEI provoking using bipolare electrode has a favorable impact on post IVF pregnancy success. Methods. Total of 81 patients had hysteroscopy performed 30-50 days prior to IVF, 40 of which had LEI made during hysteroscopy (the LEI group) using bipolar electrode in a way not described in any available literature. Remaning his- Mitić D, et al. Vojnosanit Pregl 2018; 75(6): 570-575. (52.50% vs 34.44%, p < 0.05) i 2,1 put veća šansa da se ostvari trudnoća (OR = 2,10; 95% IP: 1,04-4,26; p < 0.05). Utvrdili smo razliku u stopi implantacije između LEI i non LEI grupa s jedne i kontrolne grupe s druge strane (23,89%, 25,47% vs 18,18%, redom), ali bez statističke značajnosti. Bila je prisutna, ali ne značajno viša, stopa trudnoća i nakon prve VTO i nakon sledeće u LEI i non LEI grupi u odnosu na kontrolnu grupu. Zaključak. LEI načinjena bipolarnom elektro-dom u toku histeroskopije je jednostavna i sigurna metoda koja daje višu stopu kliničkih trudnoća i duplira verovatnoću za pozitivan ishod VTO.