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A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network
2007
BMC Systems Biology
The nuclear receptors are a large family of eukaryotic transcription factors that constitute major pharmacological targets. They exert their combinatorial control through homotypic heterodimerisation. Elucidation of this dimerisation network is vital in order to understand the complex dynamics and potential cross-talk involved. Results: Phylogeny, protein-protein interactions, protein-DNA interactions and gene expression data have been integrated to provide a comprehensive and up-to-date
doi:10.1186/1752-0509-1-34
pmid:17672894
pmcid:PMC1971058
fatcat:wbn7p5ii3rflddupj7pr5p6koy