Changes in Thyroid Nodule Volume Caused by Fine-Needle Aspiration: A Factor Complicating the Interpretation of the Effect of Thyrotropin Suppression on Nodule Size*

Donald L. Gordon, Michael Flisak, Susan G. Fisher
1999 Journal of Clinical Endocrinology and Metabolism  
The effectiveness of TSH suppression therapy for thyroid nodules remains controversial. Prior studies have assumed that the fineneedle aspiration biopsy (FNAB), used to confirm a benign condition before the establishment of control and treatment groups, has no effect on nodule volume. Seventeen untreated euthyroid patients with clinical solitary thyroid nodules that were solid (on high-resolution ultrasound) and a colloid goiter (on cytologic examination) had ultrasound measurements of nodule
more » ... rements of nodule volume before a FNAB, immediately thereafter, and 1 month and 6 months later. Size differences and individual variability at each time period were analyzed. No signif-
doi:10.1210/jcem.84.12.6195 pmid:10599720 fatcat:s62fznsgcrfphlagxgptzpfl2u