On the Importance of Mathematical Methods for Analysis of MALDI-Imaging Mass Spectrometry Data

Dennis Trede, Jan Hendrik Kobarg, Janina Oetjen, Herbert Thiele, Peter Maass, Theodore Alexandrov
2012 Journal of Integrative Bioinformatics  
SummaryIn the last decade, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), also called as MALDI-imaging, has proven its potential in proteomics and was successfully applied to various types of biomedical problems, in particular to histopathological label-free analysis of tissue sections. In histopathology, MALDI-imaging is used as a general analytic tool revealing the functional proteomic structure of tissue sections, and as a discovery tool for detecting
more » ... biomarkers discriminating a region annotated by an experienced histologist, in particular, for cancer studies.A typical MALDI-imaging data set contains 10
doi:10.1515/jib-2012-189 fatcat:6eadextsnjhrnd3bvneyf27jhq