Krüppel-like factor 15 regulates BMPER in endothelial cells

Heike L. Pahl, Franziska Volkmar, Thomas Helbing, Ulrich Goebel, Philipp Diehl, Cam Patterson, Martin Moser, Christoph Bode, Jennifer Heinke
Bone morphogenetic proteins (BMPs) are involved in embryonic and adult blood vessel formation in health and disease. Previous studies have shown that BMP endothelial cell precursor-derived regulator (BMPER) plays an important role in endothelial cell function and blood vessel formation. BMPER is a key regulator of BMP4 activity and a prerequisite for BMP pathway activation by BMP4 in endothelial cells. Here, we characterize the BMPER promoter and elucidate mechanisms of BMPER regulation.
doi:10.17615/ypd7-nw66 fatcat:t3nwzhejpnh7ncznpswv6tjgrq