History of regional chemotherapy for cancer of the extremities

Charlotte Eielson Ariyan, Mary Sue Brady
2008 International Journal of Hyperthermia  
Patients with recurrent cutaneous or soft tissue malignancies of the extremity provide a unique opportunity to evaluate therapy targeted to the isolated limb. The most common clinical presentation of recurrent extremity malignancy occurs in patients with melanoma. The extremity is the site of primary melanoma in half of patients with the disease [1], and of those with a primary melanoma of Breslow depth 1.5 mm, 15% will develop a local or in-transit recurrence [2] . Palliation of extremity
more » ... se is important in these patients, as median survival after diagnosis of in-transit or locally recurrent disease42 years [3, 4] . Radical approaches to eradication of extremity recurrence are rarely used, although in a highly selected group of patients undergoing amputation, 42% 5-year survival was reported [5] . As greater recognition of the palliative nature of extremity therapy has evolved, an emphasis on preservation of limb function has supplanted cure as a more realistic therapeutic goal. While occasional cure can be observed, it would be misleading to propose this as the likely outcome of eradication of recurrent extremity melanoma. Isolated limb perfusion (ILP) was developed as an alternative to amputation in patients with recurrent cancer of the extremity. The concept was that vascular isolation of the limb would allow delivery of higher (and potentially more effective) doses of chemotherapy to the disease in the limb than could be achieved with systemic therapy.
doi:10.1080/02656730701785102 pmid:18392997 fatcat:7cojoocyona47ap5bi4o2aheoa