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Tumor microenvironment and cancer therapy resistance
2016
Cancer Letters
Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells gain resistance through a variety of mechanisms in both primary and metastatic sites, involving cell intrinsic and extrinsic factors, but the latter often remains overlooked.
doi:10.1016/j.canlet.2015.07.044
pmid:26272180
fatcat:5o3k4jo325adpfrt2udnhmsyvq