A Novel drug delivery system for the treatment of Periodontitis was developed for site specific delivery of Aceclofenac sodium which has excellent anti inflammatory activity. Dental Implants are pharmaceutical devices in the form of strip with very small drug loading capacity and it can be formulated in the size of 0.8 x 0.4 square cm. The objective of the present study was to formulate and evaluate controlled release dosage form of Aceclofenac sodium for the topical treatment of inflammation

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... periodontitis. It is a site specific delivery device with once daily continuous delivery of Aceclofenac sodium as an anti inflammatory compound with excellent activity against the Inflammation. Dental Implants was prepared by Solvent casting technique, using polymers like HPMC K 100 , HPMC K 4 M, Gelatin and Ethyl cellulose with Dibutyl phthalate as Plasticizer. The physicochemical parameters like Thickness, Weight variation, Content uniformity and in vitro Release studies were evaluated and the drug release was found to follows Non-Fickian diffusion mechanism. Formulation F2 shows 20.93 % of drug at the end of 12 th hr and was considered as best formulation for further controlled release. The drug release data shows a best fit for korsermayer-Peppas fitting curve and obeys Zero order release kinetics.