Anti-Hu Antibody-associated Paraneoplastic Neurological Syndrome Showing Peripheral Neuropathy and Atypical Multifocal Brain Lesions

Makoto Shibata, Megumi Uchida, Setsuki Tsukagoshi, Koichi Yamaguchi, Aya Yamaguchi, Natsumi Furuta, Kouki Makioka, Toshitaka Maeno, Yukio Fujita, Masahiko Kurabayashi, Yoshio Ikeda
2015 Internal medicine (Tokyo. 1992)  
A 64-year-old Japanese woman presented with a three-month history of progressive numbness and weakness of the lower extremities. A neurological examination and nerve conduction study indicated sensorimotor polyneuropathy. Since the serum anti-Hu antibody titer was remarkably elevated, paraneoplastic neurological syndrome was highly suspected. A thoracoscopic biopsy of the hilar lymph nodes, in which 18 Ffluorodeoxyglucose uptake was obviously increased, revealed pathological findings for
more » ... ell lung cancer (SCLC). Subsequently, the patient presented with generalized tonic-clonic seizures, and cerebral MRI showed reversible multifocal brain lesions, considered to reflect paraneoplastic encephalopathy. After two courses of chemotherapy for SCLC, the brain lesions totally disappeared.
doi:10.2169/internalmedicine.54.4867 pmid:26631892 fatcat:6auvuqlvxzhfzdtcjwmpjd52eq