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Supplementary Material for: A Study on the Association of the Chromosome 12p13 Locus with Sporadic Late-Onset Alzheimer's Disease in Chinese [article]

Y. Li, L.W. Chu, Z. Li, P.-Y. Yik, Y.-Q. Song
2017 Figshare  

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Recent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and
more » ... 0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese.
doi:10.6084/m9.figshare.5120713 fatcat:b3qm34iy3vf47ldtobqcvtpuwi
Open Access
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Y. Li, L.W. Chu, Z. Li, P.-Y. Yik, Y.-Q. Song. "Supplementary Material for: A Study on the Association of the Chromosome 12p13 Locus with Sporadic Late-Onset Alzheimer's Disease in Chinese." Figshare (2017)