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The use of the orthotopic model to validate antivascular therapies for cancer
2011
International Journal of Developmental Biology
Preserved Fulltext
The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.
doi:10.1387/ijdb.103230ml
pmid:21858775
fatcat:vuk6uggzsjhn5cn7bt2flrldkm