Cell-Free Fetal DNA in Plasma of Pregnant Women: Clinical Potential and Origin

Akihiko Sekizawa, Antonio Farina, Takashi Okai
2005 Taiwanese Journal of Obstetrics & Gynecology  
Circulating fetal DNA in maternal plasma can be used for both fetal genetic testing and evaluation of complications of pregnancy. As a prenatal genetic test, the greatest advantage of using circulating fetal DNA is the lack of risk. This approach has been applied to the diagnosis of fetal gender, fetal Rhesus D (RhD) blood type, and fetal single-gene disorders. However, it only allows examination of disorders where the gene of interest is present in the fetal genome but absent from maternal
more » ... Since most fetal DNA probably originates from villous trophoblasts, concentrations can be used to evaluate damage to trophoblasts, particularly in pathologic complications of pregnancy such as pre-eclampsia, invasive placenta, hyperemesis gravidarum, and trisomy 21. Fetal DNA in the plasma of pregnant women thus offers a new source of data that can be used in various clinical settings. [Taiwanese J Obstet Gynecol 2005;44(2):116-122]
doi:10.1016/s1028-4559(09)60122-4 fatcat:hpbhgt2v2navvj5mybmdhxaskm