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Emergence of meropenem/vaborbactam resistance in KPC-producing Klebsiella pneumoniae causing bloodstream infections in northern Italy, 2018 [post]

Paolo Gaibani, Donatella Lombardo, Linda Bussini, Federica Bovo, Maddalena Giannella, Michele Bartoletti, Pierluigi Viale, Maria Carla Carla Re, Simone Ambretti
2021 unpublished

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We aimed to investigate the incidence of meropenem/vaborbactam-resistance among KPC-producing Klebsiella pneumoniae (KPC-Kp) bloodstream infection in a large Italian hospital. Meropenem/vaborbactam-resistance was found in 8% (n = 5) KPC-Kp, while 5% (n = 3) strains exhibited cross-resistance to ceftazidime/avibactam. Genomic analysis revealed that meropenem/vaborbactam-resistance was associated to non-functional OmpK35 and OmpK36 porins and no specific mutation was associated to
more » ... . No specific antimicrobial treatment was related to favorable clinical outcome, while cross-resistance was not associated to higher clinical and/or microbiological failures. Our study indicated that resistance to meropenem/vaborbactam was due to porins deficiency and is associated to reduced susceptibility both to ceftazidime/avibactam and carbapenems.
doi:10.21203/rs.3.rs-237255/v1 fatcat:pt3qsrpgcvak7mtiqj3tlmd7ki
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Paolo Gaibani, Donatella Lombardo, Linda Bussini, Federica Bovo, Maddalena Giannella, Michele Bartoletti, Pierluigi Viale, Maria Carla Carla Re, Simone Ambretti. "Emergence of meropenem/vaborbactam resistance in KPC-producing Klebsiella pneumoniae causing bloodstream infections in northern Italy, 2018." (2021)