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A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells

Chao Huang, Zhongkai Zhu, Xiyue Cao, Xingfu Chen, Yuping Fu, Zhengli Chen, Lixia Li, Xu Song, Renyong Jia, Zhongqiong Yin, Gang Ye, Bin Feng (+1 others)
2017 Molecules  

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https://web.archive.org/web/20180727120028/https://res.mdpi.com/def5020022e4dd9b6b23185728851b18641ccbfee5c4c2e27084b740e4a5ee0444c4cb79bbb2461e85fed9f795a7f4175d9df90e2a538f60efc42042f912a224b32433626518cd9f672defa526f0efebe95a23b0fed3f328be2deb982dbeba7a4c2e8dd560039f438e2dcd7eebb78e26ff21b2f6308790d46fe1dcd47ead2aa0dc2db20a398fbb6b37c6b0d9f41a5da8845e1d93891d?filename=&attachment=1

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Sijunzi Decoction (SJZD) is a formula used for the treatment of spleen deficiency and gastrointestinal diseases in Traditional Chinese Medicine. Polysaccharides are reported to be the main components of SJZD responsible for its bio-functions. However, highly purified and clearly characterized polysaccharides from SJZD are not well described. Here we obtained a purified polysaccharide (SJZDP-II-I) from SJZD using ion exchange chromatography and gel filtration. Structure analysis by FT-IR and NMR
more » ... identified SJZDP-II-I as a typical pectic polysaccharide with homogalacturonan and rhamnogalacturonan type I regions and arabinogalactan type I and II as side chains. In vitro studies indicated that SJZDP-II-I treatment could significantly enhance the total antioxidant capacity of SW480 cells, resulting from the promoted expressions of antioxidant enzymes and their master regulator PGC-1α, which would be valuable for further research and applications.
doi:10.3390/molecules22081341 pmid:28805701 fatcat:2ceawv3ttfaapkjrhr55op4wru
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Chao Huang, Zhongkai Zhu, Xiyue Cao, Xingfu Chen, Yuping Fu, Zhengli Chen, Lixia Li, Xu Song, Renyong Jia, Zhongqiong Yin, Gang Ye, Bin Feng, Yuanfeng Zou. "A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells." Molecules 22.8 (2017) 1341