Generative Aging of Brain Images with Diffeomorphic Registration [article]

Jingru Fu, Antonios Tzortzakakis, José Barroso, Eric Westman, Daniel Ferreira, Rodrigo Moreno
2022 arXiv   pre-print
Analyzing and predicting brain aging is essential for early prognosis and accurate diagnosis of cognitive diseases. The technique of neuroimaging, such as Magnetic Resonance Imaging (MRI), provides a noninvasive means of observing the aging process within the brain. With longitudinal image data collection, data-intensive Artificial Intelligence (AI) algorithms have been used to examine brain aging. However, existing state-of-the-art algorithms tend to be restricted to group-level predictions
more » ... suffer from unreal predictions. This paper proposes a methodology for generating longitudinal MRI scans that capture subject-specific neurodegeneration and retain anatomical plausibility in aging. The proposed methodology is developed within the framework of diffeomorphic registration and relies on three key novel technological advances to generate subject-level anatomically plausible predictions: i) a computationally efficient and individualized generative framework based on registration; ii) an aging generative module based on biological linear aging progression; iii) a quality control module to fit registration for generation task. Our methodology was evaluated on 2662 T1-weighted (T1-w) MRI scans from 796 participants from three different cohorts. First, we applied 6 commonly used criteria to demonstrate the aging simulation ability of the proposed methodology; Secondly, we evaluated the quality of the synthetic images using quantitative measurements and qualitative assessment by a neuroradiologist. Overall, the experimental results show that the proposed method can produce anatomically plausible predictions that can be used to enhance longitudinal datasets, in turn enabling data-hungry AI-driven healthcare tools.
arXiv:2205.15607v1 fatcat:btd3malrirddje6icytikdvmjm