Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women

Troels Wolthers, David M. Hoffman, Ailish G. Nugent, Mark W Duncan, Margot Umpleby, Ken K. Y. Ho
2001 American Journal of Physiology. Endocrinology and Metabolism  
Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women. Am J Physiol Endocrinol Metab 281: E1191-E1196, 2001.-We have determined whether oral estrogen reduces the biological effects of growth hormone (GH) in GH-deficient (GHD) women compared with transdermal estrogen treatment. In two separate studies, eight GHD women randomly received either oral or transdermal estrogen for 8 wk before crossing over to the alternate route of administration. The
more » ... istration. The first study assessed the effects of incremental doses of GH (0.5, 1.0, 2.0 IU/day for 1 wk each) on insulin-like growth factor I (IGF-I) levels during each estrogen treatment phase. The second study assessed the effects of GH (2 IU/day) on lipid oxidation and on protein metabolism using the whole body leucine turnover technique. Mean IGF-I level was significantly lower during oral estrogen treatment (P Ͻ 0.05) and rose dose dependently during GH administration by a lesser magnitude (P Ͻ 0.05) compared with transdermal treatment. Postprandial lipid oxidation was significantly lower with oral estrogen treatment, both before (P Ͻ 0.05) and during (P Ͻ 0.05) GH administration, compared with transdermal treatment. Protein synthesis was lower during oral estrogen both before and during GH administration (P Ͻ 0.05). Oral estrogen antagonizes several of the metabolic actions of GH. It may aggravate body composition abnormalities already present in GHD women and attenuate the beneficial effects of GH therapy. Estrogen replacement in GHD women should be administered by a nonoral route. insulin-like growth factor I; lipid oxidation; protein turnover
doi:10.1152/ajpendo.2001.281.6.e1191 pmid:11701433 fatcat:wsb3fmst55hgpchnlz6rxjmvqe