Objective: To study the effect of nephrotic enteral nutrition preparation on the nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition. Methods: A total of 68 patients who received maintenance hemodialysis and had malnutrition in our hospital between January 2013 and July 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table. Control group received regular dietary

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... rvention, and observation group received nephrotic enteral nutrition preparation based on routine intervention. Nutritional status and microinflammatory state before and after intervention were compared between two groups of patients. Results: Before intervention, the differences in peripheral blood levels of protein indexes and trace elements as well as serum levels of inflammatory factors were not statistically significant between two groups of patients. After intervention, peripheral blood nutrition-related proteins TP, ALB, PA, Hb and TRF levels of observation group were higher than those of control group; peripheral blood trace elements Zn and Fe levels were higher than those of control group while Ca level was lower than that of control group; serum inflammatory factors IL-6, hs-CRP and TNF-α levels were lower than those of control group. Conclusion: Nephrotic enteral nutrition preparation can effectively optimize the nutritional status and reduce the microinflammation degree in patients with maintenance hemodialysis complicated by malnutrition.