Osmotic demyelination syndrome is a disorder characterized by wide spread development of demyelination in the pontine as well as extra pontine regions. It has been a recognized complication of rapid correction of hyponatremia. However, a variety of other conditions have been associated with the development of ODS, independent of changes in serum sodium. Here we present a patient who came with features suggestive of ODS, uncontrolled hyperglycemia and recently corrected hyponatremia.