Brunner's gland hamartoma is a rare benign tumor of the duodenum. It may present with either various symptoms caused by obstruction or bleeding; or incidental mass with no symptoms. A 54-years old woman admitted to hospital for melena. Esophagogastroduodenoscopy revealed a large pedunculated polyp arising from distal portion of the duodenal bulb; erosions and hematin coatings was found overlying mucosa. Endoscopic removal was not possible due to its measures and thick stalk. The lesion was

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... ted at the base of stalk with normal mucosa via duodenotomy. Histopathologic examination revealed that this tumor was a Brunner's gland hamartoma, 5 cm in its greatest dimension. We described a case of Brunner's gland hamartoma caused upper gastrointestinal bleeding four years after the first diagnosis and related literature was reviewed.