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Systematic comparison and prediction of the effects of missense mutations on protein-DNA and protein-RNA interactions
2021
PLoS Computational Biology
The binding affinities of protein-nucleic acid interactions could be altered due to missense mutations occurring in DNA- or RNA-binding proteins, therefore resulting in various diseases. Unfortunately, a systematic comparison and prediction of the effects of mutations on protein-DNA and protein-RNA interactions (these two mutation classes are termed MPDs and MPRs, respectively) is still lacking. Here, we demonstrated that these two classes of mutations could generate similar or different
doi:10.1371/journal.pcbi.1008951
pmid:33872313
fatcat:aiu7rthwirb3zptvfc4mftj46a