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Synthesis and pharmacological evaluation of newer substituted 2-oxo/thiobarbiturinylbenzoxa/thiazepine derivatives as potent anticonvulsant agents
2015
Oriental Journal of Chemistry
Preserved Fulltext
A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substituted aminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2-(substituted-phenyl)-3-(substitutedaminomethylene)]-2,3-dihydro-1, 5-benzoxazepines (6a-6l) were synthesized. All the newly synthesized compounds were screened in vivo, for their acute toxicity and anticonvulsant activity in MES and PTZ models and were compared with standard drugs phenytoin sodium and sodium valporate. Out
doi:10.13005/ojc/310113
fatcat:fpi76hdztvbehhpso6lwk6bekm