Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis

2010 International Journal of Molecular Medicine  
7ß, is an orally bio-available synthetic derivative of naturally occurring androstene-3ß, 7ß, 17ß-triol. Our present data show that oral treatment with HE3286, favourably influenced the course of arthritis in the rat model of adjuvant-induced arthritis (reduced cumulative disease scores and paw edema), and in the mouse model of collagen antibody-induced arthritis (reduced clinical paw scores). Importantly, HE3286 was not immune suppressive in human mixed lymphocyte reaction or in animals
more » ... ged with Coxsackie B3 virus. HE3286 is currently in phase I/II clinical trials in rheumatoid arthritis and ulcerative colitis and these findings further strengthen the possibility that HE3286 may represent an effective antiinflammatory agent useful for treating chronic inflammation with a more attractive safety profile than glucocorticoids or cyclooxygenase inhibitors.
doi:10.3892/ijmm_00000385 fatcat:kuc62fiynjfirbtiuhnj6z76uy