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Effects of low-fluence-rate PDT on glioma spheroids
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
The effectiveness of low-fluence rate PDT on human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or hexyl-ALA, is investigated. Spheroid survival is monitored following PDT at representative drug concentrations, light fluences and fluence rates. It is shown that, for above threshold fluences, significant PDT response can be obtained at a fluence rate of 5 mW cm2. At this fluence rate, the response of human glioma spheroids to PDT with lipophilic ester derivatives, such asdoi:10.1117/12.469347 fatcat:uqwv7l6yibfdfdfllucohfwiiy