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Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways
Objective: Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines and is expressed in various cardiovascular disease states. CT-1 induces cardiomyocyte hypertrophy, and protects myocytes from ischemia reperfusion injury. We sought to elucidate CT-1 signaling in cardiac fibroblasts with respect to initiation of protein synthesis. Methods: Cardiac fibroblasts were isolated from the ventricles of 200-g Sprague -Dawley rats and stimulated with CT-1 at specified concentrations with ordoi:10.1016/s0008-6363(03)00534-0 pmid:14613866 fatcat:5e7wl456nzgmxk2ozoi66h7ene