AB035. The link between cognitive impairment and drusen quantity in age-related macular degeneration

Stephanie Pietrangelo, Caitlin Murphy, Sophie Hallot, Aaron Johnson
2019 Annals of Eye Science  
Age-related macular degeneration (AMD) is a common cause of severe vision impairment in populations over 50 years old. It is characterized by drusen; the accumulation of waste between the retinal pigment epithelium and Bruch's membrane. Drusen have been identified in the eyes of Alzheimer's patients, post-mortem. Further, beta-amyloid, best known as a pathological component of the senile plaques in Alzheimer's disease, has been identified as a component of drusen in AMD. Researchers have also
more » ... monstrated an increased prevalence of cognitive impairment in individuals with AMD. The current study uses optical coherence tomography (OCT) and a cognitive assessment to investigate the potential use of drusen as a biomarker of cognitive impairment. The overall number of drusen detectable on the OCT scans of individuals who exhibit mild cognitive impairment is compared to the number of drusen detectable on the OCT scans of individuals who do not exhibit mild cognitive impairment. Methods: To date, 10 participants (nine women) aged 74 to 95 years with a diagnosis of AMD and/or drusen have been recruited. The Optos® OCT/SLO imaging system was used to take cross-sectional images of the retina. The
doi:10.21037/aes.2019.ab035 fatcat:q56iuloxrvawfmwdecbvydpiv4