IgM+ memory B cells induced in response to Plasmodium berghei adopt a germinal centre B cell phenotype during secondary infection
Parasitology cambridge.org/par Research Article Cite this article: Pietrzak HM, Ioannidis LJ, Hansen DS (2020). IgM + memory B cells induced in response to Plasmodium berghei adopt a germinal centre B cell phenotype during secondary infection. Parasitology 147, 994-998. https://doi. Abstract Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses. Whereas most studies examining long-lived memory B cell responses have
... ssed on the IgG + memory B cell compartment, IgM + memory B cells have only recently started to receive attention. It has been proposed that unlike IgG + memory B cells, which differentiate into antibody-secreting plasma cells upon antigen re-encounter, IgM + memory B cells might have the additional capacity to establish secondary germinal centre (GC) responses. The precise function of IgM + memory B cells in the humoral immune response to malaria has not been fully defined. Using a murine model of severe malaria infection and adoptive transfer strategies we found that IgM + memory B cells induced in responses to P. berghei ANKA readily proliferate upon re-infection and adopt a GC B cell-like phenotype. The results suggest that that IgM + memory B cells might play an important role in populating secondary GCs after re-infection with Plasmodium, thereby initiating the induction of B cell clones with enhanced affinity for antigen, at faster rates than naive B cells. https://www.cambridge.org/core/terms. https://doi.